Product Profile
Product Name
GADD153 (phospho Ser30) antibody
Antibody Type
Primary Antibodies
Product description
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Rabbit Polyclonal antibody to GADD153 (phospho Ser30)This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP ａnd LAP (liver activator protein), ａnd preventing their DNA binding activity. The protein is implicated in adipogenesis ａnd erythropoiesis, is activated by endoplasmic reticulum stress, ａnd promotes apoptosis. Fusion of this gene ａnd FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GADD153. The exact sequence is proprietary.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WB
WB: 1:500 - 1:1000:
Species Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
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DNA-damage-inducible transcript 3
CHOP10
CHOP
CHOP-10
DDIT3
GADD153
CEBPZ
Target
GADD153
Tissue Specificity
Recognizes endogenous levels of GADD153 (pS30) protein.
Application
Application
- Western blot analysis of GADD153 (pS30) expression in HeLa (A); Raw264.7 (B); rat spleen (C) whole cell lysates.
Application Notes
WB: 1:500 - 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Shipped at 4 C. Upon delivery aliquot ａnd store at -20 C for one year. Avoid freeze/thaw cycles.
Storage Buffer
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, ａnd 0.01% sodium azide.
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