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得克萨斯大学西南医学中心免疫系伍拓琦实验室
课题组简介
实验室介绍
美国德克萨斯大学西南医学中心(UTSW)是世界著名的医学研究中心之一。西南医学中心致力于多学科交叉研究和培养基础及临床科研人员。该中心共产生过6名诺贝尔奖获得者，25名美国国家科学院院士，17名美国国家医学院院士，及14名HHMI。伍拓琦课题组隶属于免疫系和癌症中心。实验室研究方向包括：1）T细胞衰竭和干性的分子调控机制，2）建立提高肿瘤免疫疗效的新方法，3）衰老对神经中枢T细胞免疫反应的影响。
职位简介
需聘任高水平博后1名。博后的培养项目及待遇的详细信息如下
https://www.utsouthwestern.edu/education/graduate-school/postdoctoral-scholars/。
招聘要求及薪资待遇
Postdoctoral fellow position in immunology at the UT Southwestern Medical Center
A postdoctoral fellow position is available in the laboratory of Dr. Tuoqi Wu in the Department of Immunology and the Harold C. Simmons Comprehensive Cancer Center at the UT Southwestern Medical Center (https://labs.utsouthwestern.edu/wu-tuoqi-lab/people). Ongoing projects in the laboratory include: 1) understanding the molecular mechanism of T-cell stemness and T-cell exhaustion, 2) identifying novel targets for improving the efficacy of cancer immunotherapy, and 3) understanding age-associated immune dysfunction in the CNS. Studies will utilize cutting-edge next-generation sequencing, genome editing, bioinformatics as well as molecular and cellular immunology approaches.
Dr. Wu received his PhD degree from Emory University. He performed his postdoctoral research at the National Institutes of Health (NIH). Dr. Wu is currently an assistant professor in the Department of Immunology at the UT Southwestern Medical Center. His research is supported by the NIH, Cancer Research Institute, V foundation, American Federation for Aging Research, and generous startup fund from UT Southwestern.
Relevant publications:
Zhu Z, Luo Y, Lou G, Yihunie K, Wizzard S, DeVilbiss AW, Muh S, Ma C, Shinde SS, Hoar J, Hu T, Zhang N, Biswal S, DeBerardinis RJ, Wu T*, Yao C*. The redox sensing KEAP1 facilitates adaptation of T cells to chronic antigen stimulation by preventing hyperactivation. Science Immunology. 2024; 9(101):eadk2954. *corresponding author
Zhu Z, Lou G, Teng X, Wang H, Luo Y, Shi W, Yihunie K, Hao S, DeGolier K, Liao C, Huang H, Zhang Q, Fry T, Wang T, Yao C*, Wu T*. FOXP1 and KLF2 reciprocally regulate checkpoints of stem-like to effector transition in CAR T cells. Nature Immunology, 2024 Jan;25(1):117-128. PMID: 38012417 *corresponding authors.
Yao C*, Lou G, Sun HW, Zhu Z, Sun Y, Chen Z, Chauss D, Moseman EA, Cheng J, D’Antonio MA, Shi W, Shi J, Kometani K, Kurosaki T, Wherry EJ, Afzali B, Gattinoni L, Zhu Y, McGavern DB, O’Shea JJ, Schwartzberg PL, Wu T*. BACH2 Enforces the Transcriptional and Epigenetic Programs of Stem-Like CD8 T cells. Nature Immunology, 2021 Mar;22(3):370-380. PMID: 33574619 *corresponding authors.
Yao C, Sun HW, Lacey NE, Ji Y, Moseman EA, Shih HY, Heuston EF, Kirby M, Anderson S, Chen J, Khan O, Handon R, Reilley J, Fioravanti J, Hu J, Gossa S, Wherry EJ, Gattinoni L, McGavern DB, O'Shea JJ*, Schwartzberg PL*, Wu T*. Single-Cell RNA-Seq Reveals TOX as a Key Regulator of CD8+ T cell Persistence in Chronic Infection. Nature Immunology, 2019 Jul;20(7):890-901. PMID: 31209400 *corresponding author
Complete List of Papers:
https://www.ncbi.nlm.nih.gov/myncbi/1dq6nbpme5ZMHQ/bibliography/public/
Candidates must hold a recent Ph.D. and/or M.D. degree. Experience in immunology, cancer biology, cell biology, neuroscience or relevant fields leading to publication in peer-reviewed journals is recommended.
As one of the leading premier academic medical centers worldwide, UT Southwestern integrates pioneering biomedical research with exceptional clinical care and education. The institution’s faculty has received six Nobel Prizes and includes 25 members of the National Academy of Sciences, 17 members of the National Academy of Medicine, and 14 Howard Hughes Medical Institute Investigators. The full-time faculty of more than 2,800 is responsible for groundbreaking medical advances and is committed to translating science-driven research to new clinical treatments. Information on our postdoctoral training program, benefits, and a virtual tour can be found at http://www.utsouthwestern.edu/postdocs.
Interested individuals should send a CV, statement of interests, and a list of three references to:
Tuoqi Wu PhD
UT Southwestern Medical Center 5323 Harry Hines Blvd.
Dallas, TX 75390
https://profiles.utsouthwestern.edu/profile/208407/tuoqi-wu.html
UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status
申请材料
应聘条件
申请人需已获得或即将获得生物学方面的博士学位，包括免疫、癌症、细胞生物学、神经或其他相关领域的博士学位。有处理小鼠或病人样品经验者优先。有处理高通量测序经验者优先。有意应聘者请将简历发至。
实验室网页
https://profiles.utsouthwestern.edu/profile/208407/tuoqi-wu.html
简历投递方式（可选任一）：
1. 扫描二维码投递简历；
3. 点击链接投递简历：https://jinshuju.net/f/ZqXwZt
课题组招聘广告请发送至：bioarthr@bioart.com.cn
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