dhea吃多长时间有效果?dhea吃法空腹还是饭后?
dhea吃多长时间有效果?dhea吃法空腹还是饭后?
dhea吃多长时间有效果?dhea吃法空腹还是饭后?
DHEA有改善卵巢早衰的作用,可以调节患者体内多种激素的分泌,控制对雌性激素和雄性激素在体内的平衡,对卵巢功能退化者起到一定的作用。一般患者要服用3个月以上才能吃到作用,而且效果还需要看患者的体质或者卵巢功能下降的程度,每个人的体质不同,对药物的吸收能力也不一样,会影响药物发挥作用,而卵巢功能下降比较厉害的患者需要长时间服用才能达到效果。注意平时一定要养成良好的作息规律,多吃新鲜的蔬菜水果,增强自身免疫的功能。Hu
在服用dhea的过程当中,据有关数据表明,一般需要服用6周左右才会有效果。一天的服用量为75mg,每天早中晚各服用25mg,在饭前进行服用,一般这样服用的效果会比较好,对于卵巢功能会有一定的改善,最好是要谨遵医嘱进行服用dhea,擅自服用容易对身体产生伤害。
禁忌人群:对于睾酮水平比较高,患有多囊卵巢综合征的人要禁止服用。
As early as 2010, Margaret E. Dr. Wierman's paper, published in the Journal of Clinical Endocrinology and Metabolism, revolutionized the history of DHEA, he said: "We do not have any data to support the use of testosterone or DHEA alone for women, nor do we have any evidence that there is a need for testosterone or DHEA alone for women with and Rogen deficiency syndrome. Specifically, fertility is a complex system, and not just a single testosterone solution for ovarian function, cognitive decline, cardiovascular disease, metabolic disease, and sexual dysfunction." In summary: he means to solve fertility problems, there are some limitations in DHEA supplementation alone, and the therapeutic effect is not ideal. And then there are the insecurities that DHEA brings, such as genetic mutations, the quality of more eggs is worse, too many sacs to eat, and so on, so from now on in North , Europe, DHEA has been taken off the shelves. Since then, it has been based on a safe approach to solving the problems that women have with their childbearing due to endogenous and exogenous factors, the American Endocrine Society, in conjunction with the American College of Obstetricians and Gynecologists, the American Society for Reproductive Medicine, the European Endocrine Society and the International Menopause Society, jointly appointed a working group, the published guidelines for the treatment of DHEA AMH, a compound fertility repair factor, were re-evaluated. DHEA AMH meaning analysis: DHEA balances the hormone levels of the mother before conception, and AMH increases the egg's reserve function. DHEA AMH fully replaces DHEA.
早在2010年美国内分泌协会副主委,科罗拉多大学的Margaret E. Wierman教授在the Journal of Clinical Endocrinology and Metabolism杂志上发表的一篇文章,彻底改变了DHEA的历史,他说:“我们没有任何数据支持对女性单一的使用睾酮或DHEA,也没有任何证据表明需要对雄激素缺乏综合征女性患者单一的使用睾酮或DHEA治疗。具体的说,生育是一个复杂的系统,不是一个睾酮就能简单的解决卵巢功能、认知减退、心血管疾病、代谢性疾病、以及性障碍的。”
总结:他就是说想要解决生育问题,单纯补充DHEA存在一定的局限性,治疗效果不够理想。
同时还有DHEA带来的不安全性,比如带来基因突变、补多了卵子质量更差、多囊不能吃等,所以自此北美、欧洲,全面的下架了DHEA。
自此以通过安全的方式解决女性因内源性、外源性问题影响生育为基础,美国内分泌学会联合美国妇产科医师学会、美国生殖医学学会、欧洲内分泌学会和国际绝经学会共同任命一个工作小组,重新评估已发表的关于影响生育各种因素,并发出了复合备孕修复因子DHEA AMH治疗指南。DHEA AMH意义解析:DHEA 平衡受孕前母体的激素水平,AMH增加卵子的储备功能。DHEA AMH全面替代DHEA。
复合备孕修复因子DHEA AMH——多系统治疗指南
自然怀孕试管——如何有健康的卵子和胚胎着床的环境
DHEA AMH意义解析:DHEA 平衡受孕前母体的激素水平,AMH增加卵子的储备功能.
女性受孕就是精子和卵子相遇并到达子宫的生理过程:
(1)首先是内外生殖系统发育正常,保证性生活正常进行,输卵管的拾卵、输送卵子、受精并输送 受精卵至宫腔的功能良好。
(2)女性内分泌轴下丘脑-垂体-卵巢功能正常,有成熟 卵泡排出,形成黄体并功能健全。
(3)子宫内膜的增殖期、分泌期的周期性变化 利于受精卵着床,以上环节中有任何一个异常,均可导致受孕障碍。(dhea吃多长时间有效果?dhea吃法空腹还是饭后?)
Decreased ovarian reserve function is the main cause of difficult pregnancy in women over 28 years of age. It was found that DHEAMH could increase the quantity and quality of oocytes and embryos, increase the rate of pregnancy and decrease the risk of abortion in patients with decreased ovarian function, increase the rate of high-quality embryos and AMH level in patients with normal ovarian reserve, improve pregnancy outcomes. In a double-blind randomized controlled study, there was no significant change in ovarian AFC in dheamh-supplemented and non-supplemented women, but the number of high-quality embryos increased significantly, which may be due to the reduction of embryo aneuploidy in dheamh-supplemented women. The results showed that the number of primordial follicles, primary follicles and secondary follicles increased significantly, and the atresia of follicles was improved. Clinical results suggest that DHEA supplementation may present a risk, but DHEAMH supplementation with energy-intensive oocytes is too low to detect a risk, and DHEAMH and vitamin E supplementation together, it can not only enhance the effect of vitamin E, increase IVF rate and clinical pregnancy rate, but also decrease FSH, increase AFC and AMH, and improve ovarian responsiveness. The scientists used the DHEAMH test on aging mice. After a period of quantitative oral DHEAMH treatment, the aging mice gave birth to more babies, and the survival rate of the mice increased. This experiment proves that DHEAMH can not only increase the number of follicles but also improve the quality of eggs. The certification body determined that DHEAAMH had a drug effect but no toxic side effects.
卵巢储备功能降低是大于28岁女性怀孕困难的主要原因。观察发现,DHEAAMH可提高卵母细胞及胚胎的数量和质量增加卵巢功能降低患者妊娠率、降低流产风险;可提高龄卵巢储备正常患者的优质胚胎率和AMH水平,改善妊娠结局。
双盲随机对照研究发现,补充和未补充DHEAAMH者卵巢AFC无明显变化,但优质胚胎数量显著增加,原因可能为DHEAAMH能够降低胚胎非整倍性。给予DHEAAMH干预,结果原始卵泡、初级卵泡、次级卵泡数量均有明显增加,卵泡闭锁情况有所改善。
临床结果表明:补充DHEA可能会带来风险,但是补充DHEAAMH密集能量卵源太未发现风险,并且DHEAAMH和维生素E同时补充,不仅提升维生素E的作用、提高试管受精率和临床妊娠率,还降低FSH,增加AFC和AMH,提高卵巢反应性。科学家对年迈的小鼠进行了DHEAAMH实验,经过一段周期的定量口服DHEAAMH实验,年迈的小鼠产仔数量增加的同时,小鼠的存活率也增加了。通过这个实验证明 DHEAAMH不仅可以提升卵泡的数量还可以提高卵子的质量。认证机构确定DHEAAMH具有药物作用但没有其毒副作用。
今天小编来告诉你三个卵巢功能的检查方法!大家行动起来咯~
虽说大姨妈是卵巢功能的晴雨表,然而光盯着大姨妈是远远不够的。真的等到月经都不来了再去操心卵巢的功能,可能已经来不及。
所以对于备孕努力了一年以上未果的小姐姐,卵巢功能是一个必查项目。
一看月经第2-3天基础FSH
检查方法:月经见红第2-3天查血
FSH是由卵巢的上级领导脑垂体分泌的激素小天使。他掌管着卵子的生长,这就是促卵泡刺激素的含义。
卵巢的工作能力可以从她的上级领导脑垂体给出的命令强度来推断。
当卵巢功能正常的时候,上级领导就只需要给出恰到好处的指令就好,这时FSH值通常在2-8IU/L之间。
一旦卵巢能力变差,对排卵这事变得懈怠,那么上级领导要用“重锤”督促工作了。来自脑垂体的命令信号强度越大,说明卵巢功能越弱。如果FSH>10IU/L,说明卵巢功能有下降的迹象。
在女性进入围绝经期的前几年,这个数字会持续走高,从20IU/L到30IU/L再到40IU/L。随着FSH的不断升高,生育力也就慢慢降低到零了。
二看AMH
抽血检查随时可做 与月经周期无关
AMH由卵巢中的窦卵泡分泌。女性的卵子储备总量从出生开始就是固定的,随着女性每个月一批卵子的发育和排出,这个库存量就会稍微地降低一点。
卵巢储备越多,AMH数值就越高;
反之,卵巢储备越少,AMH数值就越低。
➙对于30岁以前生育力旺盛的小姐姐,AMH至少是3ng/ml或4ng/ml;
➙对于多囊的姑娘,AMH高达7ng/ml或8ng/ml;
➙对于40岁生育力较低的姐姐,AMH很可能已经下降到1ng/ml以下,这时的卵巢已经属于低反应状态了。(dhea吃多长时间有效果?dhea吃法空腹还是饭后?)
如果说FSH是通过脑垂体发来的指令强度,来间接推断卵巢功能,那么AMH就是直接从卵巢中卵泡们的劳动果实中来衡量。
AMH可以说比FSH更直接和更准确地体现了卵巢的状态,医生们也越来越看重这个数值。
三看B超检查卵巢 细数基础窦卵泡数
月经见红第2-3天阴道超声检查
对于这种在流血的日子去做阴道B超的检查方式,很多小姐姐是不理解的。没有办法,就是要在这个时候乘着卵子还没长起来的时候,去数一数卵巢中窦卵泡的个数呀!这个方法比较前两个方法而言更直接了当呢。
通常情况下,一个周期内单侧卵巢的窦卵泡数5-10颗算合适。如果双侧的基础窦卵泡数在5-7个以下,甚至只有2-3个,说明卵巢储备下降咯。
这些检查可以反映并评估卵巢储备卵巢:
➀化验:
月经期FSH、LH、雌激素以及AMH。
➁超声波检测:
在分辨率较好的阴道超声下,可知卵巢里的窦卵泡数。
In order to eliminate the individual difference as far as possible, this study adopted self-control study before and after, and DHEAAMH used before and after two times, test tube, cycle of superovulation protocol consistent. The results showed that DHEAMH significantly increased the indexes of ovarian reserve function, such as basal FSH, AFC and AMH, after three months of DHEAMH treatment, suggesting that DHEAMH may have an effect on improving ovarian reserve function. AMH is mainly secreted by preantral and antral follicles. When DHEAAMH was used, the two indexes of AMH and AFC related to antral and antral follicles were improved, suggesting that DHEAAMH may promote the development of antral antral follicles, it plays a role in the development of early follicles in women with poor ovarian function, thus increasing the number of AFC and the expression of AMH secreted by early follicles. On the basis of improving ovarian reserve function, this study found that DHEAMH significantly increased the number of eggs harvested, fertilized and high-quality embryos, indicating that DHEAMH improved ovarian responsiveness. In this study, DHEAMH is pursuing good water solubility, safety and non-toxicity, high biological activity and easy to be absorbed by human body. Ovarian stem cells stop proliferation and differentiation after aging, so that ovarian follicular pool can not be replenished, leading to ovarian function decline stop ovulation. Therefore, the aging of ovarian stem cells may be the fundamental cause of the decline of ovarian function. Many studies have shown that the proliferation and differentiation of ovarian stem cells are regulated by immune factors (immune cells, immune factors) . In this experiment, after DHEAMH treatment, compared with the control group, the expression of immune factor protein in the high, middle and low dose groups was significantly higher, and the number of ovarian follicles increased synchronously, while the function of macrophages was enhanced, the results showed that DHEAMH could enhance the reproductive function of female while regulating the reproductive function by immune function.
本研究为尽可能消除个体差异,采用自身前后对照研究,且DHEAAMH使用前、后两次 试管 周期的超促排卵方案一致。 研究结果显示DHEAAMH使用三个月,卵巢储备功能的相关指标,如基础 FSH、 AFC、 AMH 显著提高, 提示DHEAAMH可能具有改善卵巢储备功能的效应。
AMH 主要由窦前及小窦状卵泡这类早期卵泡所分 泌,当DHEAAMH使用后早期卵泡相关的 2 个指标 AMH 及 AFC 均得到改善,提示DHEAAMH可能通过促进 卵巢功能不好的女性早期卵泡的发育而发挥作用,从而提高 AFC 的 数目及早期卵泡所分泌的 AMH 的表达。 在卵巢储备功能改善的基础上,本研究发现DHEAAMH使用后,相应的获卵数、受精数和 优质胚胎数也均显著增高,表明 DHEAAMH使用后卵巢反应性提高。
DHEAAMH在研究中追求水溶性好、安全无毒、生物活性高、易被人体吸收。卵巢干细胞衰老后停止增殖、分化,使卵巢卵泡池无法得以补充,从而导致卵巢功能衰退停止排卵。可见,卵巢干细胞衰老可能是卵巢功能衰退的根本原因。诸多研究表明,卵巢干细胞增殖、分化受机体免疫因素( 免疫细胞、免疫因子)的调控。本实验中,DHEAAMH服用后治疗后,高、中、低剂量组与对照组相比,免疫因子蛋白表达量明显较高及巨噬细胞功能增强的同时,卵巢卵泡数同步增多,验证了免疫功能调控生殖功能的同时,表明DHEAAMH具有增强雌性生殖功能的作用。
敲黑板
卵巢功能三个重要数值:
FSH、AMH、AFC数
卵巢功能很重要,掌管排卵和激素
三个指标查一查,生育水平早知道
(dhea吃多长时间有效果?dhea吃法空腹还是饭后?)
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