围绕传统中医药研究，本期精选发表在《辽宁中医杂志》的5篇双语文章，欢迎阅读！
精选文章·Selected Articles
01
足三里及内关埋针治疗对腹腔镜下全子宫切除术后患者胃肠功能的影响
Effect of Intradermal Thumbtack Needle Buried in Zusanli (ST36) and Neiguan (PC6)on Gastrointestinal Function after Laparoscopic Hysterectomy
【摘要】目的 探讨揿针穴位埋置对腹腔镜下全子宫切除术后患者胃肠功能的影响。方法 选取2020年10月—2022年10月该院行腹腔镜下全子宫切除手术的100例患者为研究对象，采用随机数字表法分为试验组及对照组，每组50例。试验组患者在双侧内关及足三里两个穴位共4个部位埋针，对照组患者进行常规术后护理。观察两组胃肠道功能恢复情况(术后首次排气及排便时间、肠鸣音状况)和不良反应发生情况。结果 排除了4例数据记录不全的患者后，最终纳入研究的试验组及对照组患者分别为49例及47例。与对照组比较，试验组胃肠道功能恢复更快，在术后首次排气时间(11.7 hvs24.2 h,P<0.001),排便时间(48.3 hvs72.4 h,P<0.001)及肠鸣音恢复时间(6.5 hvs48.0 h,P<0.001)等各项观察指标上具有显著改善。另一方面，试验组患者术后胃肠道相关并发症的发生率也明显低于对照组。除外术后48 h恶心呕吐发生率的比较差异无统计学意义，在术后6 h、12 h、24 h恶心呕吐症状发生率及术后6 h、12 h、24 h、48 h腹胀症状发生率的对比中，两组数据均具有统计学意义(P<0.05)。结论 足三里及内关穴揿针埋置能缩短腹腔镜下全子宫切除术后患者首次排气、排便及肠鸣音恢复时间，同时还能够有效降低患者术后出现恶心、呕吐及腹胀等胃肠道不良反应的发生率。
【Abstract】ObjectiveTo observe the clinical effect of bilateral intradermal thumbtack needle buried in Zusanli (ST36) and Neiguan (PC6) on gastrointestinal function after laparoscopic hysterectomy.MethodsA total of 100 patients who underwent laparoscopic hysterectomy in the hospital from October 2020 to October 2022 were recruited and randomly divided into study group and control group, with 50 patients in each group respectively.The patients in the study group were given acupuncture treatment on bilateral Zusanli (ST36) and Neiguan (PC6), while those in the control group only received routine postoperative care. The time to gastrointestinal function recovery including the first postoperative passing gas, defecation and bowel sound recovery and the occurrence of adverse events including abdominal distention, nausea and vomiting were recorded. All these data was analyzed statistically.ResultsExcluding 4 patients with the missing data, 49 patientsin the study groupand 47 patientsin the control group were includedrespectively. Compared with that of the control group, the gastrointestinal function of the patients recovered faster in the study group. The relative parameters including time to postoperative passing gas (11.7 h vs 24.2 h,P< 0.001),the time to defecation (48.3 h vs 72.4 h,P< 0.001) and the time to bowel sound recovery (6.5 h vs 48.0 h,P< 0.001) were significantly improved.Moreover, the incidence of postoperative gastrointestinal complications in the study group was significantly lower than that in the control group. Although there was no statistical difference in the incidence of nausea and vomiting at 48 h after surgery between the two groups, the incidence of nausea and vomiting at 6 h, 12 h and 24 h after surgery and the incidence of abdominal distension at 6 h, 12 h, 24 h and 48 h after surgery were significant (P< 0.05).ConclusionIntradermal thumbtack needle buried in Zusanli (ST36) and Neiguan (PC6) can shorten the recovery time of passing gas and the defecation and bowel sound of patients after laparoscopic hysterectomy, and can also effectively reduce the incidence of postoperative gastrointestinal adverse events such as nausea, vomiting and abdominal distension.
02
基于“金水相生，肺肾相关”探讨特发性肺纤维化的病机与证治
L Exploring Pathogenesis and Treatment of Idiopathic Pulmonary Fibrosis on Basis of Principle of “Mutual Generation between Metal and Water and Lung and Kidney Being Related”
【摘要】特发性肺纤维化(idiopathic pulmonary fibrosis, IPF)是呼吸系统中极为难治的疾病，其预后极差而治疗手段有限，严重威胁人类健康。IPF属中医“肺痹”“肺萎”范畴，发病在肺，病久则及肾。文章基于金水相生、肺肾相关的理论基础，探讨IPF与肺肾相关的病因病机演变，认为特发性肺纤维化属于本虚标实，虚实混杂之病，虽然病位在于肺，但与肾密切相关。提出从肺肾气虚、阴虚、阳虚三个主要方面论治IPF,同时兼顾化痰祛瘀，肺肾同治，以期对中医临床治疗IPF有所裨益。
【Abstract】Idiopathic pulmonary fibrosis (IPF) is an extremely difficult disease to treat in the respiratory system, with a very poor prognosis and limited treatment options, posing a serious threat to human health.IPF belongs to the category of “lung paralysis” and “lung atrophy” in traditional Chinese medicine (TCM), which develops in lung and affects kidney in the long run.Based on the theoretical basis that mutual generation between metal and water and lung and kidney are related, this article discussed the evolution of the etiology and pathogenesis of IPF in relation to lung and kidney, and concluded that IPF is a disease of deficiency at its origin and mixed with deficiency and excess, and that although the disease is situated in lung, it is closely relevant tokidney.It is suggested that the treatment of IPF should be based on the three main aspects of deficiency of Qi, Yin and Yang in lung and kidney, while at the same time taking into account the treatment of phlegm and elimination of blood stasis, with a view to benefiting the clinical treatment of IPF in traditional Chinese medicine.
03
基于网络药理学探讨苦参治疗结直肠癌活性成分、作用靶点及潜在作用机制
Exploring Active Components, Targets and Potential Mechanisms of Kushen (Sophorae Flavescentis Radix) in Treatment of Colorectal Cancer Based on Network Pharmacology
【摘要】目的 使用网络药理学方法分析抗肿瘤中药苦参活性成分及其治疗结直肠癌的潜在靶点与作用机制。方法 通过中药系统药理学数据库与分析平台(TCMSP)数据库筛选中药苦参活性成分，并使用PubChem数据库验证所收集活性成分化合物结构，运用SwissTargetPrediction数据库反向分子对接预测苦参活性成分可能作用靶点。采用GeneCards、DisGeNET、TTD、MalaCards数据库预测结直肠癌疾病靶点，通过Cytoscape 3.8软件构建“药物-活性成分-靶点-疾病”关系网络图，利用STRING数据库分析苦参-结直肠癌共同靶蛋白PPI蛋白间相互作用网络，采用DAVID数据库对关键靶点进行基因本体论(GO)富集分析以及京都基因和基因组百科全书(KEGG)通路富集分析。结果 共筛选获得中药苦参活性成分45个，通过调控结直肠癌相关作用靶点54个，参与体内信号传导、蛋白质磷酸化、凋亡等生物学过程，并通过调控癌症相关信号通路、PI3K-Akt信号通路、癌症蛋白聚糖信号通路等途径发挥治疗作用。结论 中药苦参能够通过多途径、多靶点协同发挥抗结直肠癌作用。
【Abstract】ObjectiveThe active components of anti-tumor Chinese medicine Sophorae Flavescentis Radix and their potential targets and mechanisms of action in the treatment of colorectal cancer were analyzed using a network pharmacology method.MethodsThe active components of Sophorae Flavescentis Radix were screened through the database of traditional Chinese medicine system pharmacology and analysis platform TCMSP database, and the structures of the collected compounds were verified using the PubChem database. The GeneCards, DisGeNET, TTD and MalaCards databases were used to predict the disease targets of colorectal cancer, and the “drug–active component–target–disease” relationship network diagram was constructed by Cytoscape 3.8 software, and the STRING database was used to analyze the common target protein of Sophorae Flavescentis Radix and colorectal cancer. Protein–protein interaction (PPI) network, Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were used for key targets using DAVID database.ResultsA total of 45 active components of Sophorae Flavescentis Radix were screened and obtained, and played a therapeutic role by regulating 54 colorectal cancer-related targets, participating in biological processes such as signal transduction, protein phosphorylation and apoptosis in vivo, and regulating cancer-related signaling pathways, PI3K-Akt signaling pathway, cancer proteoglycan signaling pathway and other pathways.ConclusionSophorae Flavescentis Radix can synergistically exert anti-colorectal cancer effects through multiple pathways and multiple targets.
04
从“痰瘀互结”论治缺血性中风
Treating Ischemic Stroke from Perspective of “Interaction of Phlegm and Blood Stasis”
【摘要】随着人口老龄化和肥胖人群的加剧，中风已成为我国主要的致残和致死类疾病，其中缺血性中风人群约占80%,更应引起高度关注。中医药防治中风有悠久的历史和优势。缺血性中风的病因主要涉及“风、火、痰、虚、瘀”,基本病机为“本虚标实”,“本虚”包罗“气血虚损、阴虚阳衰、肝肾不足”等，而“标实”却离不开“痰瘀互结”,常因气机受阻，气血不畅，生痰致瘀，痰瘀互结，闭阻脑络，发为中风。“痰瘀互结”构成中风的高危病因、关键病机和干预核心。临床从“痰瘀互结”论治缺血性中风，在杨保林教授“调五脏养脑髓”的基础上，化痰通络，达到气机通畅、气血调和的状态，不管哪种类型的缺血性中风，都能起到很好的防治效应。今后需进一步关口前移，治未病，减少发病率、复发率，尽可能获益最大。
【Abstract】With the aging of the population and the increase of obese people, stroke has become a major disabling and fatal disease in our country. Among them, the population of ischemic stroke accounts for about 80%, which deserves more attention. Traditional Chinese medicine has a long history and advantages in preventing and treating stroke. The etiology of ischemic stroke mainly involves wind, fire, phlegm, deficiency and blood stasis. The basic pathogenesis is “deficiency in origin and excess in superficiality”. “Deficiency in origin” includes “deficiency of Qi and blood, deficiency of Yin and Yang, and insufficiency of liver and kidney. However, “excess in superficiality” is inseparable from the “interaction of phlegm and blood stasis”, blockage of Qi and blood, obstruction of Qi and blood, and obstruction of the veins, which constitute the susceptibility syndrome, high risk factors and key pathogenesis. Clinically, it treats ischemic stroke effectively by “expelling phlegm and promoting blood circulation” with the instructions of Prof. YANG. In the future, it is necessary to move forward to prevent the disease, reduce the incidence rate and recurrence rate and benefit greatly.
05
刘新敏治疗子宫肌瘤的临床经验总结
Summary of LIU Xinmin’s Clinical Experience in Treating Uterine Fibroids
【摘要】子宫肌瘤是女性最常见的良性肿瘤，危害女性的身心健康，造成巨大的经济损失。刘教授指出妇人以血为本，而癥瘕一证，病因非一，总归平素失于调理、内为七情所伤，外有六淫为患，加之妇人产褥不善调护，劳逸失宜，多食生冷腥腻，多受风冷入袭，与血搏结，新陈干忤，瘀、寒、痰、浊凝滞，诸症皆作。故子宫肌瘤治法概要主要着重于整体调治，其病机根本在于血瘀，又分为气滞血瘀、寒凝血瘀、血虚血瘀、气虚血瘀等不同证型，临证治法亦需灵活参变。现作者将刘新敏教授治疗子宫肌瘤的经验进行总结，以供各位同道借鉴。
【Abstract】Uterine fibroids are the most common benign tumors in women, which harm women’s physical and mental health and cause huge economic losses. Professor LIU has pointed out that women are based on blood. But abdominal mass has many causes, it always ascribes to loss of body conditioning, seven emotions hurting and six evils attacking, in addition to the poor care during the puerperal period, inappropriate work and leisure, eating raw cold fishy greasy food and wind and cold entering the body, blood stasis, cold and phlegm stagnation, leading to all kinds of symptoms. Therefore, the summary of the treatment of uterine fibroids mainly focuses on the overall treatment, and its pathogenesis lies in blood stasis, which can be divided into different syndrome types such as Qi stagnation and blood stasis, cold coagulation and blood stasis, blood deficiency and blood stasis and Qi deficiency and blood stasis. The author summarized professor LIU Xinmin’s experiences in the treatment of uterine fibroids in order to provide reference for colleagues.
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《辽宁中医杂志》是综合性中医药学术月刊。1958年创刊。辽宁省卫生健康委员会主管，辽宁中医药大学主办。开设论著臻新、经验撷菁、学术探讨与论述、临证经纬、衷中参西、方药纵横、针灸与推拿、医案医话、实验研究、综述等栏目。适宜各级中医、中西医结合工作者和中医爱好者阅读。
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