近日，石正丽教授团队在Nature reviews microbiology杂志发表了一篇名为“Characteristics of SARS-CoV-2 and COVID-19”的综述。

文章详细概括了COVID-19病原体SARS-Cov-2的病毒学特征， 并且比较了SARS-CoV-2与人类已知病毒间的差异；此外，本章 总结了目前已知的COVID-19的临床、流行病学和病理学特征，以及目前SARS-CoV-2感染的动物模型和治疗方法研究进展；并且详细讨论了SARS-CoV-2的潜在野生动物宿主和人畜共患来源。

（图一 SARS-CoV-2、SARS-CoVs和其他β冠状病毒全长基因组序列系统发育树）

（图二 COVID-19的临床特征）

（图三 SARS-CoV-2的复制及其潜在治疗靶点）

【Abstract】

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease, named ‘coronavirus disease 2019’ (COVID-19), which threatens human health and public safety. In this Review, we describe the basic virology of SARS-CoV-2, including genomic characteristics and receptor use, highlighting its key difference from previously known coronaviruses. We summarize current knowledge of clinical, epidemiological and pathological features of COVID-19, as well as recent progress in animal models and antiviral treatment approaches for SARS-CoV-2 infection. We also discuss the potential wildlife hosts and zoonotic origin of this emerging virus in detail.

本期编辑：Lisa