殷善叶教授课题组主要利用转基因小鼠模型、原代细胞CRISPR/Cas基因编辑系统、人源组织异种移植瘤（PDX）及类器官（PDO）等工具，结合多种高通量测序技术及单细胞活体成像，开展肿瘤演化的遗传学和表观遗传学分析及肿瘤免疫治疗的基础和转化研究。因科研工作需要，课题组现招聘实验生物学或生物信息方向博士后4名，及全奖博士和访问学者若干。爱因斯坦医学院位于纽约市布朗克斯区，是美国首屈一指医学教育、基础研究和临床研究机构。课题组研究经费充足，将为入选者创造优良的工作环境和合作交流机会，并提供有竞争力的薪酬和健康保险、博后公寓等全方位的福利待遇。
The Yin Lab at Albert Einstein College of Medicine is recruiting talented and motivated postdoctoral researchers and student to work on translational cancer research.
The Albert Einstein Cancer Center is one of the oldest and most established NCI-designated cancer centers in the US. It is a premier early drug development unit focused on first-in-human and biomarker-driven clinical trials of novel cancer therapeutics, associated with cutting edge multidisciplinary translational research focused on development of predictive biomarkers, tumor heterogeneity and evolutionary dynamics, and intrinsic and acquired drug resistance.
Our laboratory applies transgenic mouse models, high-dimensional omics approaches, genome editing technologies, and patient-derived samples to study the genetic basis of chronic lymphocytic leukemia (CLL), and address fundamental questions with regards to disease heterogeneity and resistance to immune checkpoint blockade (Cancer Cell 2019 [Cover Story]; Cancer Cell 2021; Cancer Research 2021; Cell Reports 2017; Cancer Discovery [in press]). Our research will focus on the mechanisms by which signals produced by myeloid cells with distinct functions, adaptive and innate immune cells impinge on solitary tumor cell behavior. Recent NIH-funded projects include discovering tumor-microenvironment interaction in CLL, and immune regulation of head and neck cancer metastasis initiation. We will be able to interrogate the problems at hand with genetic mouse models and the most advanced imaging tools including longitudinal tissue specific intravital imaging and spatial transcriptomics. The position offers an exciting opportunity to work closely with basic and translational scientists in a highly collaborative and stimulating environment. This position is remunerated above NIH guidelines and provided with a generous package of institutional benefits and postdoctoral housing.
- Job Requirements
The candidate should have a Ph.D. or an M.D./Ph.D or equivalent training. The position seeks applicants with a strong background in one or more relevant areas including molecular biology, genome editing, development of animal modelsand computational biology. Skills and knowledge in NGS data analysis or PDX models are preferred.
- How to apply
Applicants should submit a cover letter and the curriculum vitae (preferably in a single PDF file). All application materials should be sent by email to the lab P.I. Dr. Shanye Yin at shanye.yin.einstein@gmail.com
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