Antibody Type
Primary Antibodies
Key Feature
Clonality
Polyclonal
Product Profile
Product Name
WHSC2 Antibody (Center)
Isotype
Ig
Host Species
Rabbit
Tested Applications
WB
WB~~1:100~500:
Species Reactivity
Human
Concentration
1 mg/ml
Purification
Target Information
Gene Synonyms
WHSC2
Alternative Names
More
WHSC2
NELFA
Negative elongation factor A
Wolf-Hirschhorn syndrome candidate 2 protein
Molecular Weight(MW)
57277 Da
Function
More
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex ａnd causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Probably required to interact with the RNA polymerase II complex
Tissue Specificity
Ubiquitous. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney ａnd pancreas. Expressed at lower level in adult lung. Expressed in fetal brain, lung, liver ａnd kidney
Cellular Localization
Nucleus.
Database Links
Entrez Gene
7469
Nucleotide Accession
NP_005654.3
Application
Application
- WHSC2 Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the WHSC2 antibody detected the WHSC2 protein (arrow).
Application Notes
WB~~1:100~500:
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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