Product Profile

Product Name

Pkn2 Antibody (Center)

Antibody Type

Primary Antibodies

Key Feature

Clonality

Polyclonal

Isotype

Ig

Host Species

Rabbit

Tested Applications

WB

WB~~1:100~500:

Species Reactivity

Human

Concentration

1 mg/ml

Purification

Target Information

Gene Synonyms

Prk2
Prkcl2

Alternative Names

More

Pkn2
Prk2
Prkcl2
Serine/threonine-protein kinase N2
PKN gamma
Protein kinase C-like 2
Protein-kinase C-related kinase 2

Molecular Weight(MW)

111607 Da

Function

More

PKC-related serine/threonine-protein kinase ａnd Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion ａnd transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes ａnd hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression ａnd abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed ａnd direction of movement during cell migration ａnd tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity Mediates Rho protein-induced transcriptional activation via the c- fos serum response factor (SRF)

Tissue Specificity

Ubiquitous. Highly expressed in liver ａnd lung Expressed in astrocytes (at protein level). Ubiquitous

Cellular Localization

Cylasm. Nucleus (By similarity). Membrane. Cell projection, lamellipodium (By similarity) Cylasm, cytoskeleton (By similarity). Cleavage furrow (By similarity). Midbody (By similarity). Cell junction (By similarity). Note=Colocalizes with PTPN13 in lamellipodia-like structures, regions of large actin turnover. Accumulates during telophase at the cleavage furrow ａnd concentrates finally around the midbody in cytokinesis. Recruited to nascent cell-cell contacts at the apical surface of cells (By similarity)

Database Links

Entrez Gene

Nucleotide Accession

NP_848769.2

Application

Application

Application

  • Mouse Pkn2 Antibody (Center) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the Pkn2 antibody detected the Pkn2 protein (arrow).

Application Notes

WB~~1:100~500:

Additional Information

Form

Liquid

Storage Instructions

For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Storage Buffer

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.