哈佛大学医学院Hengcheng Zhang教授多篇论文陷争议

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哈佛大学医学院/南医大二附院Hengcheng Zhang教授多篇论文陷争议

近日，《IL-6/IL-6R Signaling Blockade Alleviates Chronic Allograft Rejection by Modulating Germinal Center B Cells and Allograft Inflammation in Murine Cardiac Transplantation》发表于“‌Journal of Inflammation Research”杂志，《IL-21-producing effector Tfh cells promote B cell alloimmunity in lymph nodes and kidney allografts》发表于“JCI Insight”杂志的两篇研究论文引起关注。上述两项研究均由哈佛大学医学院/南医大二附院Hengcheng Zhang教授担任第一作者。

目前，第一篇论文公开讨论的重点在于文章内2处核心图片的视觉呈现问题，第二篇论文的争议重点聚焦于文章内4处核心图表的视觉呈现问题。尽管同行已在公开平台发起问询，但关于此类问题是否具有合理解释的讨论仍在继续。

以下为基于公开素材的客观数据信息复述：

论文1标题：IL-6/IL-6R Signaling Blockade Alleviates Chronic Allograft Rejection by Modulating Germinal Center B Cells and Allograft Inflammation in Murine Cardiac Transplantation

发表期刊：‌Journal of Inflammation Research‌

作者信息：Renfei Xia, Xiaoyi Shi, Hengcheng Zhang, Wenli Zeng, Zhe Yang, Jian Xu, Jianning Wang, Yun Miao, Tao Liao

所属单位：

1

Department of Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, People's Republic of China.

2

Department of Organ Transplantation, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, 510317, People's Republic of China.

3

Department of Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210003 People's Republic of China.

4

Department of Urology, The First Affiliated Hospital of Shandong First Medical University, Jinan, 250014, People's Republic of China.

核心素材呈现：

Figure 1 and Figure 6: Unexpected overlap between images that should show different experimental conditions. I've added the coloured rectangles to show where I mean.

Figure 1D:

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Figure 6：

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论文2标题：IL-21-producing effector Tfh cells promote B cell alloimmunity in lymph nodes and kidney allografts

发表期刊：JCI Insight

作者信息：Hengcheng Zhang , Cecilia B Cavazzoni, Manuel A Podestà , Elsa D Bechu , Garyfallia Ralli , Pragya Chandrakar, Jeong-Mi Lee , Ismail Sayin, Stefan G Tullius, Reza Abdi, Anita S Chong, Bruce R Blazar, Peter T Sage

所属机构：Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA

核心素材呈现：

流式细胞术门控策略仅以摘要形式呈现，未提供单个重复图、排除标准或样本间一致的门控信息。这导致门控过程具有主观性，且阳性群体的报告具有选择性。此外，仅根据已发表的图表，观察到本文中存在多处图像高

度相似的情况：

(1)Figure 1I和Figure 4C疑似高度重复

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(2)Figure 4D和Figure 6C疑似高度重复.

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(3)Figure 1J和Figure 4D疑似高度重复.

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(4)Figure 5E内的两幅图疑似高度重复.

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截止发稿前，相关团队暂无公开回应。

https://www.pubpeer.com/publications/5E92FCD73C80CD6A1F08C5D2119615