更多招聘信息请关注BioArt人才账号

BioArt人才

西湖大学生命科学学院

贾洁敏课题组

神经血管生物学课题组简介

西湖大学生命科学学院贾洁敏Jie-Min Jia)课题组长期致力于解析脑血管与神经系统之间的相互作用机制及调控网络,聚焦中枢神经血管生物学领域的基础科学问题。

课题组目前主要研究方向包括神经血管耦合(neurovascular coupling, NVC)、血管神经信号传递(vascular-to-neural signaling)、血管源性神经调控(vascular-derived neuromodulation)以及血管运动(vasomotion)及其相关血流振荡等生理机制,并探索其在脑卒中、情绪障碍等脑疾病中的作用及潜在干预靶点。课题组的长期目标是建立高分辨率全脑神经血管连接图谱及血管源性神经调控图谱,系统解析神经活动、血管动力学与脑功能之间的相互作用规律,为精准调控脑血流、维持神经元存活及改善脑疾病提供新的理论基础和干预思路。

目前,课题组已建立成熟的神经血管研究技术平台,并在脑血流与血管调控领域取得系列研究成果。近年来,相关工作发表于Cell Research、Neuron、Advanced Science、Nature Neuroscience、Immunity、Communications Biology、Journal of Cerebral Blood Flow & Metabolism (JCBFM)等国际学术期刊。

因科研工作需要,现面向国内外公开招聘博士后2名,分别为计算方向1名和生物信息学方向1名。

About the Neurovascular Biology Research Group

The Jie-Min Jia Lab studies the interactions between cerebral blood vessels and the nervous system, focusing on neurovascular coupling (NVC), vascular-to-neural signaling, vascular-derived neuromodulation, and vasomotion, as well as their roles in brain diseases such as stroke and mood disorders. The lab aims to build high-resolution whole-brain neurovascular atlases. Recent work has been published in Cell Research, Neuron, Advanced Science, Nature Neuroscience, Immunity, and Journal of Cerebral Blood Flow & Metabolism (JCBFM).

We are recruiting two postdoctoral fellows: one in computational research and one in bioinformatics.

招聘岗位及应聘条件

岗位1:博士后(计算方向,1名)

研究方向:围绕神经血管耦合、血管运动(vasomotion)及其引起的血流动力学、氧输运和组织灌注变化开展理论与计算研究。该岗位重点并非传统生物信息学分析,而是利用数学建模、数值计算及生物物理模型,定量刻画血管动力学、血流及流体波动、氧输运以及神经-血管相互作用过程,并将理论模型与实验室获得的活体成像、生理及血流数据相结合。最终目标是构建基于真实脑血管结构和神经血管单元调控机制的虚拟脑血流系统,实现对脑血流动力学和血管动力学的计算模拟、扰动与干预,并用于筛选可调控脑血流的小分子、蛋白质及核酸类候选因子,为脑疾病新型干预策略的发现与评价提供计算模拟平台。

候选人可根据具体研究问题开展包括但不限于以下方向的工作:生物流体力学、波动传播、偏微分方程建模、时空信号分析、多物理场模拟及新型计算方法或算法开发。

应聘条件:

已获得或即将获得力学、流体力学、应用数学、物理学、生物医学工程、计算科学或其他相关专业博士学位;具有扎实的数学建模、数值计算或理论分析基础,具备独立开展科研工作的能力;熟悉流体动力学、生物流体力学、波动力学、偏微分方程、数值模拟或多物理场计算中的一个或多个方向;具有较强的编程及算法实现能力;具有独立开发或改进计算模型、数值方法或算法经验者优先;以第一作者身份在相关领域发表过高水平研究论文者优先;对将物理、数学和计算方法应用于神经科学与血管生物学问题具有浓厚兴趣,并具有良好的跨学科合作能力;年龄不超过35周岁。

岗位2:博士后(生物信息学方向,1名)

研究方向:负责课题组单细胞转录组(scRNA-seq)、空间转录组及其他多组学数据的系统分析与深度挖掘,结合神经血管生物学问题,解析不同脑区、细胞类型及疾病状态下神经-血管相互作用的分子机制。

应聘条件:已获得或即将获得生物信息学、计算生物学、统计学或其他相关专业博士学位;熟练掌握R 和/或 Python,具有扎实的数据分析和编程能力;具有丰富的单细胞测序、空间转录组或其他多组学数据分析经验;能够独立建立、优化和维护生物信息学分析流程,具备多组学数据整合及深度挖掘能力;以第一作者身份发表过相关领域高水平研究论文者优先;具备良好的独立科研能力、团队协作能力和跨学科沟通能力;年龄不超过35周岁。

Job Description

Position 1: Postdoctoral Fellow (Computational, 1)

Develop theoretical and computational models of neurovascular coupling, vasomotion, hemodynamics, oxygen transport, and tissue perfusion; integrate models with in vivo imaging and physiological data to build a virtual cerebral blood flow system for simulating perturbations and screening candidate regulators of cerebral blood flow. Research directions may include biofluid mechanics, wave propagation, PDE modeling, spatiotemporal signal analysis, and multiphysics simulation.

Qualifications: Ph.D. (or near completion) in mechanics, fluid mechanics, applied mathematics, physics, biomedical engineering, computational science, or related fields; solid foundation in mathematical modeling, numerical computation, fluid dynamics, or PDEs; strong programming and algorithm skills; first-authored papers in related fields preferred.

Position 2: Postdoctoral Fellow (Bioinformatics, 1)

Analyze the lab's single-cell transcriptomics (scRNA-seq), spatial transcriptomics, and other multi-omics data to dissect neurovascular interactions across brain regions, cell types, and disease states.

Qualifications: Ph.D. (or near completion) in bioinformatics, computational biology, statistics, or related fields; proficient in R and/or Python; extensive experience in single-cell, spatial, or multi-omics data analysis; first-authored papers in related fields preferred.

Other requirements:

Hold or expect to hold a Ph.D. degree by the start date; aged under 35.

Compensation and Benefits

1. The research team offers a competitive and negotiable compensation package commensurate with the candidate’s qualifications and experience. Applications for relevant projects and programs will be encouraged and supported.

2. The university assists with enrolling children in child care and school.

3. The university boasts comprehensive postdoctoral training, with programs including the Westlake University Outstanding Postdoctoral Fellows and Westlake Postdoctoral Fellowship for Women.

薪酬待遇

1.根据个人科研工作能力提供具有市场竞争力的薪酬,具体面议。实验室将提供稳定的工作环境与一流的研究平台,协助申报博士后相关项目等;2.学校可协助办理落户、协助对接子女的入学入托服务工作;3.学校提供全方位培养体系,设立“西湖大学优秀博士后”“西湖优秀女性博士后奖”等项目。四、资助政策1.博士后可享受杭州市在站博士后资助政策;2.对获得中国博士后科学基金资助和浙江省博士后择优项目资助的,杭州市给予1:1配套资助;3.对出站留杭(来杭)工作的博士后,杭州市给予每人40万元补助;4.对来杭工作符合条件的全球本科及以上学历应届毕业生(含毕业5年内的回国留学人员、外国人才),杭州市发放生活补贴,其中博士10万元;5.可申请认定杭州市高层次人才,并享受相应政策。

Funding

1. Postdocs receive a living allowance and research funding from the Hangzhou municipal government.

2. Recipients of funding from the China Postdoctoral ScienceFoundation or the Zhejiang Province Selected Funding for Postdoctoral Research Projects are entitled to supplementary funding of the same amount from the Hangzhou municipal government.

3. Postdocs who work full-time in Hangzhou after completing their postdoctoral research qualify for an allowance of 400,000 RMB from the Hangzhou municipal government.

4. Eligible new university graduates holding a doctoral degree or equivalent who work full-time in Hangzhou (including those who studied abroad and returned to China within 5 years of graduation, as well as foreign talent) can apply to the Hangzhou municipal government for a living allowance of 100,000 RMB.

5. Postdocs recognized as high-level talent in Hangzhou enjoy corresponding preferential policies.

简历投递

请将以下材料以PDF形式按照以下任一方式发送至邮箱,申请材料标题请注明:“应聘博士后+本人姓名”,对于符合要求并通过初审者,将会通知安排面试。招聘启事在岗位招满前有效。

1.个人简历;

2.同行专家的推荐信(2封,其中一封为博士生导师推荐信);

3.博士学历学位证明材料。

To apply, please send the following documents in English in PDF format to , and indicate "Postdoc Application" in the email subject.

1. CV.

2. 2 reference letters (one of them is from the doctoral supervisor).

3. Doctoral degree certificate.

投递简历请选择西湖大学生命科学学院贾洁敏课题组

简历投递方式(可选任一):

1. 扫描二维码投递简历;

3. 点击链接投递简历:https://data.bioart.com.cn/f/p0EB2y(复制链接至浏览器投递简历

课题组招聘广告请发送至:bioarthr@bioart.com.cn

制版人:半夏