Product Profile

Product Name

FGG Antibody

Antibody Type

Primary Antibodies

Product description

More

FGG is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen ａnd fibrin regulate cell adhesion ａnd spreading, display vasoconstrictor ａnd chemotactic activities, ａnd are mitogens for several cell types. Mutations in this protein lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia ａnd thrombophilia.1) Sie,M.P., Isaacs,A. J. Hypertens. 27 (7), 1392-1398 (2009)

Immunogen

This FGG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 417-445 amino acids from the C-terminal region of human FGG.

Key Feature

Clonality

Polyclonal

Isotype

Ig

Host Species

Rabbit

Tested Applications

FACSIHC-PWB

For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:50~100 For FACS starting dilution is: 1:10~50:

Species Reactivity

Human

Concentration

1 mg/ml

Target Information

Gene Symbol

FGG

Alternative Names

Fibrinogen gamma chain
FGG

Molecular Weight(MW)

52 kDa

Database Links

Entrez Gene

2266

Protein Accession

P02679

Application

Application

Application

  • Flow cytometric analysis of T47D cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Application

Application

  • Western blot analysis in human blood plasma cell line lysates (35ug/lane).

Application

Application

  • FGG Antibody (RB18714) IHC analysis in formalin fixed ａnd paraffin embedded human hepatocarcinoma tissue followed by peroxidase conjugation of the secondary antibody ａnd DAB staining.

Application Notes

For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:50~100 For FACS starting dilution is: 1:10~50:

Additional Information

Form

Liquid

Storage Instructions

Store at 4˚C for three months ａnd -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.