丙烷丙硫代磺酸盐（PTSO）是一种从大蒜（Allium sativum）中分离出来的一种成分，具有抗氧化、抗炎、免疫调节和抗菌作用。因此，PTSO可能会是治疗炎症性肠病的潜在候选者。

过程与结果

来自西班牙格拉纳达大学生物医学研究中心（CIBM）药理学系的Teresa Vezza、Francesca Algieri、José Garrido‐Mesa等人在两种结肠炎小鼠模型中研究了PTSO的抗炎作用：2,4-二硝基苯磺酸（DNBS）（PTSO剂量：0.01-10 mg/kg）和葡聚糖硫酸钠（DSS）（PTSO剂量：0.01-0.1 mg/kg）。PTSO（0.1-25 μM）的免疫调节作用也于体外在Caco-2和THP-1细胞中显示出来：减少了促炎介质的产生和下调了丝裂原活化蛋白激酶（MAPK）信号传导途径。该化合物通过降低不同促炎介质的表达和改善肠上皮屏障的完整性，在两种小鼠结肠炎模型中显示出了有益效果。此外，PTSO改善了在DSS诱导的结肠炎小鼠中观察到的变化的肠道微生物群组成。

PTSO在小鼠的实验性结肠炎中发挥了肠道抗炎活性。通过调节参与炎症反应的细胞活性的这种抗炎活性可能与PTSO的免疫调节特性有关。此外，PTSO能够恢复肠上皮屏障功能并改善肠道微生物群稳态，从而支撑其在人IBD中未来的发展。

该文章《The Immunomodulatory Properties of Propyl‐Propane Thiosulfonate(PTSO) Contribute to its Intestinal Anti‐Inflammatory Effect in Experimental Colitis》被《Molecular Nutrition & Food Research》首次出版于2018年12月5日。点击下方阅读原文即可查看摘要原文。

翻译/编辑：李莹；责任编辑：张睿梅

图片来源于百度图片

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