Rabbit anti-BRCA1 polyclonal antibody - middle region|anti|damage|middle|role|with

Product Profile

Product Name

Rabbit anti-BRCA1 polyclonal antibody - middle region

Antibody Type

Primary Antibodies

Immunogen

The immunogen for anti-BRCA1 antibody: synthetic peptide directed towards the middle region of human BRCA1

Key Feature

Clonality

Polyclonal

Isotype

IgG

Host Species

Rabbit

Tested Applications

WBIHC

WB:1:500~1:2000
IHC:1:50~1:200
Notes:Optimal dilutions/concentrations should be determined by the researcher.

Species Reactivity

Human

Concentration

1 mg/ml

Purification

Affinity purified

Target Information

Gene Symbol

BRCA1

Gene Synonyms

BRCAI
BRCC1
IRIS
PSCP
RNF53
PNCA4
BROVCA1
PPP1R53

Gene Full Name

Breast cancer 1, early onset

Gene Summary

The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination ａnd transcriptional regulation to maintain genomic stability. BRCA1 acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. BRCA1 plays a central role in DNA repair by facilitating cellular response to DNA repair. BRCA1 is required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase ａnd the G2 phase of the cell cycle. BRCA1 is involved in transcriptional regulation of P21 in response to DNA damage. BRCA1 is also required for FANCD2 targeting to sites of DNA damage.It may function as a transcriptional regulator. BRCA1 inhibits lipid synthesis by binding to inactive phosphorylated ACACA ａnd preventing its dephosphorylation.This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability ａnd acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, ａnd signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1-associated genome surveillance complex. This gene product associates with RNA polymerase II, ａnd through the C-terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, ａnd recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers ａnd more than 80% of inherited breast ａnd ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization ａnd physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full-length natures identified.

Alternative Names

BRCAI
BRCC1
IRIS
PSCP
RNF53
PNCA4
BROVCA1
PPP1R53

Molecular Weight(MW)

208kDa

Sequence

1863 amino acids

Database Links

Entrez Gene

672

SwissProt ID

P38398

Protein Accession