Product Profile
Product Name
Anti-WHSC2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
ELISAIHCWB
WB:1:200-1:2000
IHC:1:200-1:2000
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
NELFA
Gene Synonyms
WHSC2
NELF-A
P/OKcl.15
Gene Full Name
negative elongation factor complex member A
Gene Summary
More
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, ａnd may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted ａnd tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. [provided by RefSeq, Jul 2008]
Molecular Weight(MW)
57KD
Cellular Localization
Nucleus
Application
WB
- Western blot analysis using WHSC2 antibody against A549(1) cell lysate.
IHC
- Immunohistochemical analysis of paraffin-em
- bedded bladder cancer tissues using WHSC2 antibody with DAB staining.
IHC
- Immunohistochemical analysis of paraffin-em
- bedded esophageal cancer tissues using WHSC2 antibody with DAB staining.
Application Notes
WB:1:200-1:2000
IHC:1:200-1:2000
Additional Information
Form
Liquid
Storage Instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05% sodium azide.
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