Product Profile
Product Name
CD59 Antibody (R-79)
Antibody Type
Primary Antibodies
Modification Notes
CD59 is a GPI-anchored glycoprotein that is expressed on leukocytes, vascular endothelial cells, various epithelial cells ａnd placenta. CD59 acts together with CD58 in mediating T cell adhesion ａnd activation, ａnd it may be a second ligand of CD2. CD59 functions as a regulator of the terminal pathway of complement by binding to the C8/C9 components of the assembling membrane attack complex (MAC) on host cell membranes, to s the formation of the lytic pore. CD59 also drives both calcium release ａnd activation of lipid-raft associated signalling molecules such as tyrosine kinases. CD59 gene has two p53-responsive domains that may be implicated in the defense of host cells from damage by the complement system in inflammation, suggesting that p53 could be used to mediate susceptibility of tumor cells to the complement lysis during chemotherapy.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of CD59 of mouse ａnd rat origin by WB, IP, IF ａnd ELISA:
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epie corresponding to amino acids 23-101 representing mature CD59 of rat origin
Tissue Specificity
epie corresponding to amino acids 23-101 representing mature CD59 of rat origin
Database Links
Entrez Gene
Application
Application
- Western blot analysis of CD59 expression in rat brain tissue extract.
Application Notes
recommended for detection of CD59 of mouse ａnd rat origin by WB, IP, IF ａnd ELISA:
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide ａnd 50% glycerol.
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