Product Profile
Product Name
GRIA2 [A3-A7]
Antibody Type
Primary Antibodies
Product description
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Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system ａnd plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, ａnd thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly ａnd enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Immunogen
Recombinant protein
Key Feature
Clonality
Monoclonal
Isotype
IgG2b
Host Species
Mouse
Tested Applications
WBIHCFC
WB:1:500-1:2,000
IHC:1:50-1:200
FC:1:50-1:100
Species Reactivity
Human
Concentration
2 mg/mL.
Target Information
Alternative Names
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AMPA 2 antibody AMPA selective glutamate receptor 2 antibody AMPA-selective glutamate receptor 2 antibody AMPA2 antibody GluA2 antibody GLUR 2 antibody GLUR B antibody GluR K2 antibody GluR-2 antibody GluR-B antibody GluR-K2 antibody GLUR2 antibody GLURB antibody Glutamate receptor 2 antibody Glutamate receptor ionotropic AMPA 2 antibody Glutamate receptor ionotropic antibody Gria2 antibody GRIA2_HUMAN antibody HBGR2 antibody
Molecular Weight(MW)
99 kDa
Cellular Localization
Cell membrane. Endoplasmic reticulum membrane
Database Links
SwissProt ID
P42262
Application
Application
- Fig1: Western blot analysis of Glutamate receptor 2 on human GRIA2 recombinant protein using anti- Glutamate receptor 2 antibody at 1/1,000 dilution.
Application
- Fig2: Western blot analysis of Glutamate receptor 2 on HEK293 (1) ａnd Glutamate receptor 2-hIgGFc transfected HEK293 (2) cell lysate using anti- Glutamate receptor 2 antibody at 1/1,000 dilution.
Application
- Fig3: Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using anti- Glutamate receptor 2 antibody. Counter stained with hematoxylin.
Application
- Fig4: Flow cytometric analysis of SK-N-SH cells with Glutamate receptor 2 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).
Positive Control
Human Glutamate receptor 2 recombinant protein, Glutamate receptor 2-hIgGFc transfected HEK293 cell lysate, human rectum cancer tissues, SK-N-SH.
Application Notes
WB:1:500-1:2,000
IHC:1:50-1:200
FC:1:50-1:100
Additional Information
Form
Liquid
Storage Instructions
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
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