Fig. 1. Representative characterizations and in vitro delivery of WNP and other delivery systems.
Fig. 2.
In vivodelivery of WNP and other delivery systems.
Fig. 3. Design of SARS-CoV-2 RBD(M5)-hFc mRNA and safety evaluation of WNP .
Fig. 4. Comparation of humoral immune responses and cellular immune responses triggered by different mRNA vaccines in mice.
Fig. 5. Comparation of protective efficacy against Omicron BA.1 triggered by different mRNA vaccines.
Fig. 6. Comparation of protective efficacy against XBB.1.5-ΔN-GFP replicon delivery particles triggered by different mRNA vaccines.
Supplementary Figure S1. Full dilution-inhibition profiles and curve fitting parameters.
Supplementary Figure S2. Gating strategy for flow cytometry analysis.
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